For years she ran daytime TV — but can the “Queen of All Media” run for the highest elected office in America?

Financier and philanthropist Rubenstein asked — given Winfrey’s popularity and the fact that a woman has yet to win the White House — would she ever consider mounting her own campaign?

“I actually never thought — I never considered the question even a possibility. I just thought, oh, oh,” said Winfrey, 63, who supported Hillary Clinton in last year’s election.

While the TV mogul didn’t mention Donald Trump specifically, she hinted that his roots as a businessman and reality-TV star could make her reconsider.

“I thought, ‘I don’t have the experience, I don’t know enough,'” Winfrey said. “Now I’m thinking, ‘Oh, oh.'”